association between hla-drb1*01 and hla-cw*08 and outcome following htlv-i infection
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abstract
background: human t cell lymphotropic virus type i (htlv-i)-associated myelopa-thy/tropical spastic paraparesis (ham/tsp) is an inflammatory disease which occurs in less than 2% of htlv-i -infected individuals. high proviral load, high htlv-i-specific cd8+ cytotoxic t lymphocyte frequency (ctl) and host genetic factors such as hla all appear to be associated with htlv-i infection. previous studies have shown that hla-drb1*01 increases the risk of ham/tsp in japanese htlv-i infected individu-als. objective: to investigate the association between hla class ii drb1 alleles and hla class i alleles (hla-cw*08, b54, a*02 and a-30) in htlv-i infected individu-als in mashhad. methods: here we determined the frequency of hla class ii drb1, using inno-lipa reverse hybridization line probe assay, and hla class i alleles (hla-cw*08,b54, a*02 and a-30) by pcr-sscp method in healthy controls, ham/tsp patients and htlv-i infected individuals born and resident in mashhad. results: the frequency of hla-drb1*01 alleles in this population was different from other areas of iran. the frequency of hla-drb1*01 was significantly increased in ham/tsp patients compared with carriers (p 0.028; or=9.4). the frequency of hla-cw*08 was also significantly increased in ham/tsp patients compared with controls (p=0.03; or=13.5). conclusion: our results may suggest that possession of hla-drb1*01 increases the risk of ham/tsp in htlv-i-infected individuals and hla-cw*08 correlates with low ctl immune response in ham/tsp patients.
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Journal title:
iranian journal of immunologyجلد ۴، شماره ۲، صفحات ۹۴-۱۰۰
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